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組織蛋白去乙醯酶抑制劑(英语：HDAC inhibitor，簡寫HDI或HDAC抑制劑)是一種透過抑制身體內組織蛋白去乙醯酶功能的藥物類別，亦存在於胎兒及花椒內。現時有健康食品生產商建議透過進食花椒油而達至防癌的功效。
現時醫學界有研究透過「組織蛋白去乙醯酶抑制劑」來治療癌症[1]及神經退化病變(neurodegenerative diseases)。這些抑制劑的具體機制，例如有關的化合物如何達到有關的功效，到現在還未清楚。不過，有關文獻亦有提出可能的表觀遺傳學途徑[2] Richon et al.[3]發現HDAC抑制劑可以透過引導p21 (WAF1)來調節p53的腫瘤壓抑功能[4]。
[编辑] 參考
- ↑ Marks PA, Dokmanovic M (2005). "Histone deacetylase inhibitors: discovery and development as anticancer agents". Expert opinion on investigational drugs 14 (12): 1497-511. DOI:10.1517/13543784.14.12.1497.
- ↑ Claude Monneret (April 2007). "Histone deacetylase inhibitors for epigenetic therapy of cancer". Anticancer Drugs 18: 363-70.
- ↑ Richon VM, Sandhoff TW, Rifkind RA, Marks PA. AUG 29 2000. "Histone deacetylase inhibitor selectively induces p21(WAF1) expression and gene-associated histone acetylation." Proceedings of the National Academy of Sciences of the United States of America 97(18):10014-10019.
- ↑ el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. NOV 19 1993. "WAF1, a potential mediator of p53 tumor suppression." Cell 75(4):817-25.
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